These questions make no sense.

这些问题毫无意义。

What you say make no sense.

你说的话没有道理。

Usually this would make no sense.

这没有任何意义。

I make no sense of what he said just now.

我没明白他刚才说的话。

I think it just waste time and make no sense.

我觉得那是浪费时间与经历，毫无意义。