Feelings of guilt, worthlessness, or helplessness.

负罪感，价值感缺失或无助感。

Lack of usefulness, worth, or effect; worthlessness.

无用缺少实用性、价值或效果的；

We learn the truth worthlessness of material things.

我们了解物质的渺小。

Do you feel worthlessness or excessive guilt nearly every day?

你是否整天觉得没有价值或者很有负罪感？

He's the best physician that knows the worthlessness of most medicines.

知道大多数药物一文不值的医生，才是最好的医生。