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They also found that celecoxib blocked exogenous interleukin-6-induced STAT3 phosphorylation and nuclear translocation.
同时,他们还发现,塞来昔布阻断外源性白介素诱导的STAT 3磷酸化及核转位。
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Nuclear localization sequence(NLS) is the specific amino acid sequence on the signaling proteins to be sufficient for their nuclear translocation.
核定位序列(NLS)是信号蛋白分子上与入核转运相关的氨基酸序列。
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While heat shock promoted the phosphorylation and nuclear translocation of HSF1, the ability of this nucleus-localized HSF1 to form the DNA-binding trimer was reduced.
HSF1的亚细胞定位分析显示,HSF1主要存在于年轻细胞胞质中,热刺激促使三体形成和核转移;
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Although transmembrane receptors from cell surface to nucleus can generally regulate the cellular life activities, their pathways of nuclear translocation still remain to be elucidated.
跨膜受体可从膜表面进入细胞核内直接调控细胞的生命活动,但其核转位的途径至今尚无定论。