The house had many drawbacks, most notably its price.

这房子有很多缺陷，尤其是它的价格。

I did encounter some drawbacks and problems.

我确实遇到了一些缺陷和问题。

Wendy quite liked it, until Peter pointed out the drawbacks.

温迪很喜欢它，直到彼得指出它的缺点。

Increasing lung capacity has some drawbacks.

肺活量的增加有一些缺点。

What are the major drawbacks?

主要的缺点呢？