Because of long-standing economic troubles that preceded the housing crisis, the state has seen significant pain.

由于长期以来经济的不景气，致使两地深陷住房危机之中，从它们各自的经济状态也能明显看出，它们正处在极其痛苦的挣扎之中。

Tendon injuries due to trauma and overuse are common clinical problems that result in significant pain and loss of mobility.

肌腱损伤，由于创伤和过度是常见的临床问题，造成重大的痛苦和运动能力的丢失。

In that study about half the patients in both the real and fake acupuncture groups reported significant pain relief compared to only 27 percent of those receiving traditional back care.

在那次研究中，真针灸组和假针灸组都有近半的比例获得了显著的疼痛缓解，而相比而言这个比例在接受传统背部护理的患者中只有27%。