He has had to shoulder the responsibility of his father's mistakes.

他不得不肩负起他父亲所犯错误的责任。

You should shoulder the responsibility.

你应该承担这个责任。

It is time for us to shoulder the responsibility of protecting the environment.

是时候让我们承担保护环境责任了。

I think you should shoulder the responsibility.

我认为你应该承担责任。

I am confident that he can shoulder the responsibility.

我有信心他会肩负起责任。