What have been your biggest disappointments or challenges so far?

目前为止，最让你失望的事或最大的挑战是什么？

Surely, there will be setbacks and disappointments in life.

当然，生活中会有挫折和失望。

Like the majority of authors, he had to suffer many disappointments and rejections along the way, but these made him all the more determined to succeed.

和大多数作家一样，他在写作过程中经历过许多失望，遭受过许多拒绝，但这些都使他更加下定决心要取得成功。

How terrible its disappointments!

它带给我的失望可怕异常！

Then, one of my biggest disappointments.

在那以后，我遇到了一件最失望的事。

The disappointments of life can knock us down.

生活中种种不如意真的可以打倒我们。

But the disappointments go further back than that.

但民众对此的失望远大于其本身。

This will avoid misunderstandings and disappointments.

这会防止误会和失望。

Men's best successes come after their disappointments.

人们往往在失意之后获取大的成功。

Despite such disappointments, the lakes drove fast growth.

失望之余，湖区进入了快速发展期。

This recovery’s serial disappointments suggest he’s right.

复苏过程中一系列的曲折表明他是正确的。

On numerous occasions, he faced failures and disappointments.

他遇到过数不清的失败和挫折。

This leads to misunderstandings and disappointments for Laura.

这使劳拉产生误解、感到失望。

Disappointments come into relationships because none of us are perfect.

由于我们都是不完美的，所以人际关系中就会出现失望。

And I understood their aspirations, their disappointments and so forth.

而且我理解了他们的渴望、失望等等。

Learn how to handle setbacks. Life is made of ups, downs, and disappointments.

学会如何处理挫折，生活由顺利，挫折和失望构成。

I cared about what she needed and wanted, about her sorrows and disappointments.

我关心她的需要和希望，她的悲伤和失望。

Each day can be filled with aggravations, delays, disappointments and frustrations.

每一天都充满了恼怒、耽搁、失望和挫折。

Disappointments and reagedies in life will come and go, but happiness never leaves you.

失望和悲伤在生命中交替轮回，但幸福从不会舍你而去。

Wu says he came up with his bug-finding breakthrough after a series of career disappointments.

Wu说，他是在经历过一系列的事业低谷之后才想到这个漏洞查找方法的突破点的。