The abnormality of neurofilaments(NF) plays a possible role in axonal degeneration of Alzheimer's Disease(AD), but the mechanism remains unclarified.

阿尔茨海默病（AD）患者脑中神经细丝异常可能在其轴突退化中起重要作用，但机制不明。

Conclusion: Local high concentration of DMSO can delay axonal degeneration, which indicates that DMSO can be used for adjuvant treatment of neurodegenerative diseases.

结论：局部高浓度的DMSO能够延缓轴突的退行性病变，提示DMSO可能用于神经退行性疾病的辅助治疗。

The above changes in disconnected group were similar to those in positive control group. No obvious protective effects on axonal degeneration were observed in blank and DMSO control groups.

这种变化与阳性对照组非常相似，而空白对照组和DMSO对照组未见明显保护轴突退行性病变的作用。