It is saddening to see that relations between the two countries should have deteriorated to the present state.

两国关系恶化到今天这个地步，是令人痛心的。

But this really saddening …

这件是真的很突然…

I find public squalor very saddening.

公共场所的肮脏污秽让我感到非常悲哀。

Ignorance is more saddening than poverty.

无知比贫穷更可悲。

News of such a decline, published today in Current Biology, would be saddening in any species.

今天出版的《当代生物学》报道说，族群数量这样的骤降对于任何一种生物都是悲哀的。