ADAM-TS9, Catalytic domain, between first and second furin site; Rabbit anti.

催化结构域， 第一和第二之间融合位点； 兔抗。

In normal individual, conversion of proinsulin to insulin is mediated by two endoproteases, PC2 and PC3. There are no PC2 and PC3 but furin in hepatoma cells.

肝癌细胞内不含有PC2和PC3，不能有效地加工胰岛素原，故不能分泌成熟的胰岛素。