Clearly that has to make some difference in reference work.

很明显的是，它对于参考工作有一定的影响。

Everything we do with the limited resources we've got must make some difference on one of these metrics.

使用我们所能获得的有限资源而做的一切，都要在这些度量指标的某一个上取得成果。

The purpose of life is not to be happy. It is to be useful, to be honorable, to be compassionate, to have it make some difference that you have lived and lived well.

人生的目标不在于愉快的度过一生，而是要成为一个有用的人，一个受人尊敬的人，一个富有同情心的人，为你自己过去的惬意人生做一些改变吧。

The purpose of life is not to be happy. It is to be useful, to be honorable, to be compassionate; to have it make some difference that you have lived, and lived well.

人生的目的并不在于活得快乐，而是在于活得有用，活得光荣，活得慈悲，证明自己实实在在、健健康康的活过。

Although we talked about Vitamin D and sunlight, it can make a huge difference in how you feel if you go to a tanning salon to get some light on your skin.

尽管我们已谈到维生素D和阳光，但是如果你刻意去参加日晒沙龙来摄取阳光到皮肤的话，它会让你感觉到巨大的差别。