I looked at my wife in despair.

我绝望地看着妻子。

He gave up the struggle in despair.

他绝望地放弃了斗争。

In despair he let it alone.

在绝望中，他任其自生自灭。

He gave up the attempt in despair.

他在绝望中放弃了这种尝试。

He gave up this attempt in despair.

他在绝望中放弃了这次尝试。