How sad that all his hard work should come to nothing.

他的所有辛勤劳动竟全部付诸东流，太让人伤心了。

Their meeting had come to nothing.

他们之间的会见毫无结果。

All his hopes and plans had come to nothing.

他的一切希望和计划都成泡影。

All this effort and sacrifice has come to nothing.

所有这些努力和牺牲都白费了。

His years of efforts have finally come to nothing.

他多年的努力最终毫无结果。