She said his death was a great loss to herself.

她说他的去世对于她来说是个巨大的损失。

He has sustained a great loss by the death of his father.

他父亲的去世使他蒙受巨大的损失。

The Old Summer Palace was burned to the ground, which is a great loss in human history.

圆明园被焚烧近尽，这是人类历史上的一大笔损失。

As a result, the Amsterdam-based company suffered a great loss because of the trade war between China and America

因此，这家总部位于阿姆斯特丹的公司因中美贸易战而蒙受了巨大损失。

The company will suffer a great loss on the condition that it is forbidden to exploit this kind of alternative resource.

如果公司被禁止开发这种替代资源，公司将蒙受巨大损失。