Each requires substantial change in the way we think and function.

每个议题都需要我们在想法和职能上做根本上的改变才能因应。

The only substantial change in the results is that leverage is no longer significant.

独一的本质性的改动，成果是，杠杆率是不再具有很主要的意义。

It takes approximately six weeks to make a substantial change in a pitcher's delivery.

投手的投球要花六周才能做出实质性的改变。

But another substantial change is taking place, I think English itself is no longer really viewed as a second language.

而英语正在发生一种实质性的变化：英语本身不再被视为第二语言。