Most importantly, shrug off any ‘shoulds’.

最重要的是，摆脱任何可能性。

Most importantly, shrug off any 'shoulds'.

最重要的是，摆脱任何可能性。

Many in Japan shrug off the problem of ageing.

许多日本人对老龄化问题都不屑一顾。

It is wrong to shrug off this kind of disease.

轻视这种疾病是不对的。

It needs courage to shrug off warning from supervisors.

需要勇气去不理睬来自上司的警告。